UA-X Pro
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UA-X Pro

$55.00

UA-X Pro was crafted specifically to regulate both the production and the excretion of uric acid by supporting key metabolic enzymes in the liver and stimulating uric acid transporters in the kidney
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UA-X Pro was crafted specifically to regulate both the production and the excretion of uric acid by supporting key metabolic enzymes in the liver and stimulating uric acid transporters in the kidney.

Clinical Applications

 

 

 

 

More than a century ago, Scottish physician Alexander Haig sounded the alarm about the connection between uric acid levels in the body and cardiovascular health. Uric acid is the end item of purine metabolism in the human body and originates from catalysis by xanthine oxidase (XOD). Uric acid has a variety of physiological effects, including modulation of immune responses, regulation of blood pressure, and controlling the balance between antioxidants and prooxidants in the body. It is important to note that either overgeneration or reduction of uric acid can lead to an overabundance of uric acid.

What Is Uric Acid

Uric acid is a waste product that is produced when the body breaks down purines, which are compounds found in certain foods and also produced by the body. Uric acid is normally dissolved in the blood and excreted from the body through urine. The prevalence of uric acid in the population has increased rapidly in recent years and has a closely interdependent relationship with certain metabolic health challenges. According to the NHANES study, uric acid prevalence rates in the United States is 20.2% in men and 20.0% in women.

Serum uric acid is an independent biomarker of cardiometabolic health. Studies have clearly shown an association between hyperuricemia and oxidative stress. This is linked to cardiovascular health challenges.(*) Reactive oxygen species (ROS) are generated in tandem with uric acid production; therefore, uric acid causes endothelial changes that require a large pool of antioxidants. Uric acid also modulates vascular endothelial function through the downregulation of nitric oxide production. UA-X Pro was crafted specifically to regulate both the production and the excretion of uric acid by supporting key metabolic enzymes in the liver and stimulating uric acid transporters in the kidney.

What Is Uric Acid?

Problems with Elevated Uric Acid 

UA-X Pro was crafted specifically to regulate both the production and the excretion of uric acid by supporting key metabolic enzymes in the liver and stimulating uric acid transporters in the kidney. Elevated uric acid levels in the blood, a condition known as hyperuricemia, can potentially lead to several health risks and complications. Here are some dangers associated with elevated uric acid levels:

1. Gout: One of the most well-known risks of elevated uric acid levels is the development of gout. Gout is a type of arthritis that occurs when urate crystals accumulate in the joints, leading to sudden and severe pain, swelling, and inflammation. Chronic hyperuricemia increases the risk of developing gout.

2. Kidney stones: High levels of uric acid in the blood can contribute to the formation of kidney stones. Uric acid crystals can deposit in the kidneys and form stones, causing symptoms such as severe pain, blood in the urine, and difficulty urinating.

3. Kidney disease: Persistent hyperuricemia (elevated uric acid) can also contribute to the progression of chronic kidney disease. Elevated uric acid levels may damage the kidneys over time and impair their function, increasing the risk of kidney problems and complications.(*)

4. Hypertension: Studies have shown a potential link between hyperuricemia and hypertension (high blood pressure). It is suggested that uric acid may contribute to changes in blood vessel function and cause endothelial dysfunction, which can lead to hypertension.

5. Cardiovascular disease: Some research has suggested that high uric acid levels may be a risk factor for cardiovascular disease, including heart attacks, strokes, and atherosclerosis. Hyperuricemia levels contribute to inflammation, oxidative stress, and endothelial dysfunction, which are factors associated with cardiovascular problems.(*)

6. Metabolic syndrome: Hyperuricemia has been linked to metabolic syndrome, a cluster of conditions that increase the risk of cardiovascular disease and type 2 diabetes. Elevated uric acid levels are associated with insulin resistance, obesity, dyslipidemia, and hypertension, all components of metabolic syndrome.

7. hyperuricemia cause live disease.(*) Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease.

It’s important to note that not everyone with elevated uric acid levels will experience these complications, and individual factors play a role in determining risk. If you have concerns about your uric acid levels or related health conditions, it’s advisable to consult with a healthcare provider for evaluation, diagnosis, and appropriate management.

Lowering Uric Acid Levels

Suggested Use:

3 capsules per day or as recommended by your health care professional.

Overview
More than a century ago, Scottish physician Alexander Haig sounded the alarm about the connection between uric acid levels in the body and cardiovascular health.1 Uric acid is the end item of purine metabolism in the human body and originates from catalysis by xanthine oxidase (XOD).2 Uric acid has a variety of physiological effects, including modulation of immune responses, regulation of blood pressure, and controlling the balance between antioxidants and prooxidants in the body.3 It is important to note that either overgeneration or reduction in the excretion of uric acid can lead to an overabundance of uric acid.
The prevalence of uric acid in the population has increased rapidly in recent years and has a closely interdependent relationship with certain metabolic health challenges.4 According to the NHANES study, uric acid prevalence rates in the United States is 20.2% in men and 20.0% in women.5 Furthermore, serum uric acid is an independent biomarker of cardiometabolic health.6 Studies have clearly shown an association between increased uric acid concentrations and oxidative stress. This has been shown to be linked to cardiovascular health challenges.6 Reactive oxygen species (ROS) are generated in tandem with uric acid production; therefore, uric acid causes endothelial changes that require a large pool of antioxidants. Uric acid also modulates vascular endothelial function through the downregulation of nitric oxide production. UA-X Pro was crafted specifically to regulate both the production and the excretion of uric acid by supporting key metabolic enzymes in the liver and stimulating uric acid transporters in the kidney.
Vitamin C
Vitamin C has long been known for its benefits in supporting the immune system. Vitamin C must be obtained from food because the human body cannot manufacture this nutrient. In a meta-analysis of randomized controlled trials containing 1013 participants, pooled findings showed that vitamin C supplementation has a significant impact on lowering serum uric acid levels.7 Furthermore, a 20-year study published in the Archives of Internal Medicine that included almost 47000 males found that those taking vitamin C had a 44% reduced incidence of uric acid.8
Quercetin Dihydrate
Quercetin is an important dietary polyphenol, a family of micronutrients that includes flavonoids, which have potent antioxidant properties and help to maintain normal inflammatory balance. Quercetin also acts as an immune regulator that may reduce the development of cellular oxidative damage. It is found in a variety of botanicals as well as vegetables and fruits, including apples, berries, onions, broccoli, and green leafy vegetables. Quercetin inhibits advanced glycation end products (AGEs), which are harmful oxidative byproducts formed in the body because of overactive chemical reactions. Most importantly, quercetin has been shown to inhibit the actions of xanthine oxidoreductase (XOR), which is the rate-limiting step in the body’s production of uric acid.9 In a prominent 2016 study of healthy adults, a month of daily quercetin at 500 mg resulted in significantly lowered uric acid levels.10 Additionally, a study of individuals at risk for cardiovascular challenges showed a statistically significant effect of quercetin supplementation in maintaining blood pressure already within the normal range.11
Luteolin
Luteolin is naturally concentrated in many fruits and vegetables, such as citrus fruits, broccoli, and green peppers, and herbs, such as thyme, rosemary, and oregano. Certain bioactive compounds in these plants and herbs inhibit the XOR enzyme.12 In fact, luteolin has been shown to have uric acid-lowering properties comparable to traditional therapies.13 In a 2017 double-blind, placebo-controlled study of people with uric acid, it was found that ingestion of luteolin for four weeks reduced serum uric acid levels.14 Flavonoids are further known for their ability to help maintain normal inflammatory balance and antioxidant properties, and luteolin, specifically, has been shown to be liver protective against uric acid free radical stress.15
Tart Cherry
Tart cherries are known to contain anthocyanins and are believed to have many health benefits, including reducing oxidative stress and uric acid levels. One study shows that a low dose of tart cherry powder decreases serum uric acid and supports kidney function.16 Additionally, a 2021 study with 48 participants found that tart cherry ingestion can transiently decrease uric acid and a single powdered capsule is most effective for lowering uric acid.17
Xanthine Oxidase Inhibitors: Celery Seed Extract and Apple Polyphenols
Celery is an umbelliferous plant that has been shown to reduce uric acid levels and help maintain normal inflammatory balance. Specifically, celery seed in an aqueous extract (CSAE) has been shown to reduce the levels of XOD. In addition, CSAE reduced the levels of reactive oxygen species and increased the serum levels of superoxide dismutase and glutathione peroxidase.18 More so, a randomized, double-blind, parallel placebo-controlled clinical trial involving 62 volunteers randomized to 300 mg of apple polyphenols extract found a positive effect on vascular oxidative stress, endothelium function, and maintenance of healthy blood sugar levels by inhibiting XOD.19
Directions
3 capsules per day or as recommended by your health care professional.
Does Not Contain
Gluten, yeast, artificial colors or flavors.
References
  • Perlmutter, David. Drop Acid. Hachette UK, 3 Mar. 2022.
  • Sica DA, Schoolwerth AC. Part 1. Uric acid and losartan. Curr Opin Nephrol Hypertens. 2002 Sep;11(5):475-82. doi: 10.1097/00041552-200209000-00001. PMID: 12187310.
  • Bobulescu IA, Moe OW. Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis. 2012 Nov;19(6):358-71. doi: 10.1053/j.ackd.2012.07.009. PMID: 23089270; PMCID: PMC3619397.
  • Hao S, Zhang C, Song H. Natural Products Improving Hyperuricemia with Hepatorenal Dual Effects. Evid Based Complement Alternat Med. 2016;2016:7390504. doi: 10.1155/2016/7390504. Epub 2016 Oct 25. PMID: 27847526; PMCID: PMC5099468.
  • Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016. Arthritis Rheumatol. 2019 Jun;71(6):991-999. doi: 10.1002/art.40807. Epub 2019 Apr 15. PMID: 30618180; PMCID: PMC6536335.
  • Gagliardi AC, Miname MH, Santos RD. Uric acid: A marker of increased cardiovascular risk. Atherosclerosis. 2009 Jan;202(1):11-7. doi: 10.1016/j.atherosclerosis.2008.05.022. Epub 2008 May 21. PMID: 18585721.
  • Liu XX, Wang XX, Cui LL. Association between Oral vitamin C supplementation and serum uric acid: A meta-analysis of randomized controlled trials. Complement Ther Med. 2021 Aug;60:102761. doi: 10.1016/j.ctim.2021.102761. Epub 2021 Jul 16. PMID: 34280483.
  • Choi HK, Gao X, Curhan G. Vitamin C intake and the risk of gout in men: a prospective study. Arch Intern Med. 2009 Mar 9;169(5):502-7. doi: 10.1001/archinternmed.2008.606. PMID: 19273781; PMCID: PMC2767211.
  • Zhang C, Wang R, Zhang G, Gong D. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. Int J Biol Macromol. 2018 Jun;112:405-412. doi: 10.1016/j. ijbiomac.2018.01.190. Epub 2018 Jan 31. PMID: 29410028.
  • Shi Y, Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr. 2016 Mar 14;115(5):800-6. doi: 10.1017/S0007114515005310. Epub
  • 2016 Jan 20. PMID: 26785820.
  • Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, Andrica F, Ahmed A, Aronow WS, Muntner P, Lip GY, Graham I, Wong N, Rysz J, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016 Jul 12;5(7):e002713. doi: 10.1161/ JAHA.115.002713. PMID: 27405810; PMCID: PMC5015358.
  • Liu N, Xu H, Sun Q, Yu X, Chen W, Wei H, Jiang J, Xu Y, Lu W. The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors. Oxid Med Cell Longev. 2021 Mar 26;2021:1470380. doi: 10.1155/2021/1470380. PMID: 33854690; PMCID: PMC8019370.
  • Adachi SI, Oyama M, Kondo S, Yagasaki K. Comparative effects of quercetin, luteolin, apigenin and their related polyphenols on uric acid production in cultured hepatocytes and suppression of purine bodies-induced hyperuricemia by rutin in mice. Cytotechnology. 2021 Jun;73(3):343-351. doi: 10.1007/s10616-021-00452-9. Epub 2021 Feb 2. PMID: 34149170; PMCID: PMC8167080.
  • Hirano M, Takeda S, Hitoe S, Shimoda H. Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia. Integr Mol Med. 2017 Mar 30. DOI: 10.15761/IMM.1000275.
  • Ghorbani A, Rashidi R, Shafiee-Nick R. Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review. Biomed Pharmacother. 2019 Mar;111:947-957. doi: 10.1016/j.biopha.2018.12.127. Epub 2019 Jan 8. PMID: 30841474.
  • Li R, Tan Y, Li Y, Zhu X, Tang X, Zhang L, Chen J. Effects of Tart Cherry Powder on Serum Uric Acid in Hyperuricemia Rat Model. Evid Based Complement Alternat Med. 2020 Jul 22;2020:1454305. doi: 10.1155/2020/1454305. PMID: 32774405; PMCID: PMC7396008.
  • Hillman AR, Uhranowsky K. Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity. Plant Foods Hum Nutr. 2021 Mar;76(1):83-89. doi: 10.1007/ s11130-021-00879-7. Epub 2021 Jan 27. PMID: 33506357.
  • Li S, Li L, Yan H, Jiang X, Hu W, Han N, Wang D. Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep. 2019 Nov;20(5):4623-4633. doi: 10.3892/mmr.2019.10708. Epub 2019 Sep 26. PMID: 31702020; PMCID: PMC6797962.
  • Cicero AFG, Caliceti C, Fogacci F, Giovannini M, Calabria D, Colletti A, Veronesi M, Roda A, Borghi C. Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study. Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201700373. Epub 2017 Sep
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