What Is Pregnenolone?
Pregnenolone is a pre-hormone that is essential for the synthesis of many stress, sex, and neuron hormones. The starting material to make testosterone, estrogen, progesterone, cortisol, and and many others first starts with pregnenolone. Because pregnenolone plays an important part in the production of hormones, declining levels can contribute to hormonal imbalance and result in several mental and physical complications.
Pregnenolone is derived from cholesterol and is primarily produced by the adrenal cortex. It is also produced by the brain and gonad glands.
- Supports the immune system, mood and memory health‡
- Helps support hormones in the body‡
- Made with hypoallergenic, vegan ingredients
What Are the Symptoms of Low Pregnenolone?
Symptoms related to low pregnenolone include:
- Difficulties paying attention
- Memory loss
- Fatigue
- Joint and muscle pain
- Hair loss
- Dry skin
- Excessive fatigue
- Decreased sex drive
Because pregnenolone is a precursor for several other steroids and hormones in the body, deficiency can have a profound impact on several bodily functions. Restoring healthy levels with a high-quality dietary supplement can help to address these symptoms.
What Are the Main Benefits of Taking Pregnenolone?

1. Cognitive & Memory Function
Taking pregnenolone can have a fantastic effect on your cognitive function, as it helps to increase the growth of neurons in the brain. By enhancing the production of myelin, a fatty layer that insulates nerves and boosts their function, it leads to the formation of new synapses and acts as a neuroprotector. Studies have also shown that pregnenolone improves learning and memory.
2. Improves Mood, Depression & Anxiety
It has been shown that low levels of pregnenolone and allopregnanolone are linked to depression and anxiety and therefore supplementing their levels can have significant mood-boosting effects. Not only that, but it has also been proven to help control emotions, reduce negative emotional responses and improve function in social and emotional situations.
3 Improves Sleep Performance
Studies have shown that pregnenolone and its derivative allopregnanolone, can stimulate deep sleep, making it ideal for patients who suffer from sleep disturbance or insomnia.
Human studies have shown that supplementing with pregnenolone increases the amount of time that a person spends in deep sleep (slow wave sleep). This, in turn, can have a positive impact on mood, anxiety and even memory, helping to consolidate the other benefits of pregnenolone.
4. Aids Weight Loss
Pregnenolone inhibits the production of cortisol, which is one of the reasons it is such an effective stress reducer. This has the added benefit of aiding weight loss, as cortisol increases stomach fat. Similarly, by reducing cortisol levels, pregnenolone has the effect of naturally boosting testosterone levels which can increase metabolism and lead to weight loss.

Side Effects
As with all supplements, we recommend that they are taken under the supervision of a doctor or qualified expert, as improper use can cause unwanted side effects. With pregnenolone, this is particularly important, as it has such a key role to play in the day to day function of your body.
What Is The Source?
The compound diosgenin is extracted from wild yam and undergoes a proprietary synthetic process to develop the pregnenolone compound. The human body cannot metabolize wild yam into pregnenolone. This process can only take place in a laboratory. Hypoallergenic plant fiber is derived from pine cellulose.
Recommendations
• Pure Encapsulations®recommends 10–30 mg daily, with a meal, preferably in the morning or early afternoon.
• Pregnenolone should only be used under the direction and supervision of a health professional.
Are There Any Potential Drug Interactions?
Pregnenolone may inhibit drugs used to increase GABA activity (e.g., Neurontin); these drugs are frequently used in the treatment of epilepsy and depression.*





