Nitric Oxide Ultra (120 capsules)
$59.60
Gluten Free
Non GMO
Vegan
Vegetarian
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org*
- Promotes healthy blood flow*
- Supports vascular health*
- Made with hypoallergenic, vegan ingredients
Nitric Oxide Ultra (capsules) supports healthy nitric oxide production to promote healthy blood flow. Nitric Oxide Ultra contains CranLoad™ cranberry and grape extract to offer vascular support, as well as heavy flow-mediated dilation.*
Healthy blood flow: Nitric Oxide Ultra (capsules) offers a blend of CranLoadTM and citrulline to support healthy blood flow by targeting nitric oxide production and flow-mediated dilation. The formula centers around CranLoadTM, a novel fruit blend developed as part of an extensive research program with the Institute of Nutrition and Functional Foods (INAF) and Université Laval in Quebec, Canada.
CranLoadTM delivers a unique cranberry and grape seed blend that has been the subject of several trials.
Cranberries and grapes are particularly generous sources of proanthocyanidins and polyphenols. In addition to being powerful antioxidants, these compounds offer specific vascular support mechanisms that are associated with enhanced endothelial function.
Research indicates that CranLoadTM provides statistically significant support for healthy flow-mediated dilation (FMD), an effect similar to arginine administration. FMD reflects blood vessel dilation mediated by nitric oxide synthase (NOS), an enzyme that generates the endogenous vasodilator, nitric oxide. In a pilot study, CranLoadTM supplementation increased FMD within 30 minutes and remained elevated for 2 hours (Figure 1). The peak increase in brachial artery diameter following consumption of the CranLoadTM beverage was 2.8% at 60 minutes.
A similar physiological effect has been demonstrated with arginine in which supplemental arginine at doses ranging from 3–21 g increased FMD on average 1.98%. Citrulline is included to support nitric oxide production by NOS in the blood vessel endothelium and other tissues.
Research indicates that citrulline increases plasma arginine in a dose dependent manner and to a greater degree than arginine supplementation. Unlike arginine, citrulline is not metabolized before it reaches systemic circulation.
Athletic Recovery: In a double-blind, placebo-controlled, pilot study, the effects of pre-exercise CranLoadTM administration was investigated in high-profile athletes. The athletes performed a 3 km stationary cycling time trial after consuming either CranLoadTM or a placebo.
Results of the pilot study show a significant decrease in blood lactate in those athletes consuming CranLoadTM compared to placebo (Figure 2). This study supports the concept that CranLoadTM enhances blood flow and is associated with enhanced lactate clearance during high-intensity exercise. This outcome suggests enhanced recovery.*
Figure 2. Effects of CranLoadTM on blood lactate pre- and post-exercise. Data from the pilot study reveals a 30% reduction in blood lactate following warm up, and reduced lactate is maintained throughout exercise.*
What Is The Source?
CranLoadTM is derived from a proprietary blend of cranberry extract derived from Vaccinium macrocarpon fruit and grape seed extract derived from Vitis vinifera. L-Citrulline is derived from corn glucose fermentation. Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil.
Recommendations
Pure Encapsulations recommends 2–4 capsules daily, in divided doses, between meals.
Are There Any Potential Side Effects Or Precautions?
If pregnant or lactating, consult your physician before taking this product. In research studies, grape seed extract has been associated with headache, abdominal pain, sore throat, nausea and cough, but these effects occur at rates similar to placebo. Consult your physician for more information.
Are There Any Potential Drug Interactions?
Cranberry and grape seed may be contra-indicated with blood thinning medications. Consult your physician for more information.
| Ingredients | Nitric Oxide Ultra (capsules) Supplemental Facts Amount Per Serving two vegetarian capsules contain: l-citrulline (free-form)1,000 mg. CranLoad™ proprietary blend382 mg providing cranberry (Vaccinium macrocarpon) extract (fruit) and grape (Vitis vinifera) extract (seed) other ingredients: vegetarian capsule (cellulose, water), ascorbyl palmitate 2 capsules, 1-2 times daily, between meals. |
|---|