
Health Benefits
One of NAC’s most important jobs is to help your body replenish its glutathione stores. As one of your body’s most potent antioxidants, glutathione helps to get rid of cell-damaging free radicals. Reducing oxidative stress can help to lower your risk of developing chronic conditions such as heart disease, diabetes, and infertility.NAC does more than just aid in the production of glutathione.
Benefits & Features
- Promotes healthy lung tissue and respiratory function‡
- Supports cellular antioxidant defense system as a radical scavenger that supports glutathione levels in tissues‡
- Helps support tissue detoxification‡
- Convenient, easy-to-swallow capsule
- Made with high-quality ingredients backed by verifiable science
Helps Relieve Respiratory Disease Symptoms
Evidence suggests NAC may be an effective treatment for certain respiratory conditions, such as chronic bronchitis or chronic obstructive pulmonary disease (COPD). Many of these airway conditions are characterized by excess mucus production and inflammation. Although the body produces mucus to protect itself from contaminants in the air, too much of it can impede proper breathing and decrease lung function.
NAC is thought to help break apart and thin mucus secretions in the airways, making it easier to expel and clear the airway through coughing.
May Help Improve Certain Mental Health Conditions
There’s preliminary evidence that NAC may help improve certain mental health conditions. For example, a small 2018 study found that NAC improved symptoms of schizophrenia when used in addition to antipsychotic medication. The supplement was associated with an improvement in negative symptoms, including emotional expression , thought and speech productivity and motivation, as well as a better attention span[1].
Evidence also supports NAC for treating other mental health conditions, such as substance use disorders, obsessive compulsive disorder (OCD) and mood disorders. However, more research is needed to determine the effectiveness of NAC in these conditions.
May Improve Brain Health
Some research suggests NAC may improve brain health and help reduce symptoms associated with some neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. It may also help relieve neuropathic pain caused by central nervous system damage.
More research is needed to confirm the effects of NAC on brain health. Still, the supplement’s ability to increase glutathione levels and help protect against oxidative stress—a disturbance in the balance between the production of free radicals and antioxidant defenses that can cause cell damage—may contribute to its neuroprotective effects.
FDA Approved for Acetaminophen Poisoning
NAC is a commonly used—and FDA-approved— drug for treating acetaminophen poisoning. Taken in large doses, acetaminophen can cause damage to the liver. When administered through oral or intravenous routes, NAC may reduce the extent of this damage—although it cannot reverse damage that has already been done.
NAC is believed to work by increasing glutathione levels, which function as a powerful detoxifier in the liver. The glutathione then helps inactivate N-acetyl-p-benzoquinone imine (NAPQI), a toxic byproduct of acetaminophen. However, prompt administration is crucial. Research shows NAC is most effective when given within eight hours of ingesting acetaminophen.
May Help Treat Certain Viral Infections
“NAC’s potential activity against SARS-CoV-2 is still under clinical studies. However, there are clinical studies to support its use to decrease the severity, duration and frequency of influenza, common colds, recurrent bronchitis and recurrent pneumonia,” says Jia-Yia Liu, M.D., an infectious disease specialist.
Research suggests NAC works against viral infections by boosting the immune system, reducing inflammation and preventing the replication of viruses. While continued research is needed to confirm these effects, NAC supplements may offer some benefits for people struggling with viral infections.
May Improve Chronic Kidney Disease
Chronic kidney disease (CKD) is a condition that occurs when your kidneys are damaged and can’t function properly. As a result, the body can’t get rid of waste and excess fluid, leading to other health concerns—including high blood pressure and heart disease.
Some research suggests supplementation of NAC may have the potential to help slow the progression of CKD. Further research is needed to determine the effectiveness of NAC in CKD
Indications
- Ages 18 and up
- Lung health and respiratory function support‡
- Antioxidant immune system support‡
- Detoxification support‡
Suggested Use
As a dietary supplement, take 1 capsule, 1–2 times daily, between meals.
Science & Research
Verifiable Science
N-Acetyl-L-Cysteine (NAC) is a derivative of the dietary amino acid L-cysteine.1 NAC has a high affinity for lung tissue, which it supports through mucolytic and antioxidant action. Due to its sulfur content, NAC is able to disrupt disulfide bonds within mucus, thinning and easing its expulsion.2 NAC is a free radical scavenger and thus supports epithelial cell health and healthy cilia activity in the respiratory tract.3 NAC is also a precursor to the antioxidant glutathione, and supplemental NAC increases tissue levels of glutathione.4
As fundamental components of the immune system, lymphocytes rely on glutathione to function properly. Tissues enhanced with glutathione support overall antioxidant protection and help to maintain a healthy immune response.5 A multicenter, randomized, double-blind trial with 262 participants indicated that NAC supplementation for six months supported upper respiratory tract and immune system health.6 A recent meta-analysis of eight double-blind, placebo-controlled trials provided additional support for NAC’s ability to support respiratory tract health.7‡
References
- Sansone RA, et. al. Innov Clin Neurosci. 2011 Jan; 8(1): 10-14.
- Tse HN, et. al. Chest. 2013 Jul;144(1):106-18.
- Tirouvanziam R, et. al. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4628-33.
- Dauletbaev N, et. al. Eur J Med Res. 2009 Aug 12;14(8):352-8
- Teskey G, et. al. Front Immunol. 2018 Sep 12;9:2069.
- De Flora S, et. al. Eur Respir J. 1997 Jul;10(7):1535-41.
- Grandjean EM, et. al. Clin Ther. 2000 Feb;22(2):209-21.
Additional Information
Warning
If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Storage
Store in a cool, dry place.
Source
- N-acetyl-L-cysteine is synthetically derived.
- Vitamin C (as ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.











