Name: Mucosagen
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The mucosal epithelium serves multiple purposes including allowing nutrients from the diet to be absorbed and digested while simultaneously serving as a barrier that protects against unwanted food particles, toxins and microorganisms from passing directly into the body. Mucosagen includes a synergistic blend of ingredients that support the health of the GI lining while maintaining normal inflammatory balance and liver detoxification pathways to support overall health.

Under healthy conditions, the GI tract contains a semipermeable epithelial mucosal barrier which protects against the unwanted passage of food antigens, toxins, and microorganisms from crossing directly into the bloodstream. Several factors can affect the integrity of the epithelial barrier, including medications (particularly NSAIDs), stress, alcohol intake, injury, trauma, microbial imbalance and poor nutrition. Reducing the impact of these factors and preserving a healthy GI tract is critical for maintaining long-term health.

Leaky Gut and The Mucous Barrier

Leaky gut syndrome. If your intestinal barrier is impaired, it may be letting toxins into your bloodstream. Mucosagen is a comprehensive formula designed to help support and nourish the gut barrier.

The mucous layer of the gut barrier serves multiple purposes, including allowing nutrients from the diet to be absorbed and digested while simultaneously serving as a barrier that protects against unwanted food particles, toxins, and microorganisms from passing directly into the body. When a breakdown in the gut barrier occurs, there can be increased inflammatory signaling, increased epithelial permeability (leaky gut), and dysbiosis of the microbiota. (2)

Mucosagen includes a synergistic blend of ingredients that support the health of the Gut lining while maintaining normal inflammatory balance and liver detoxification pathways to support overall health.

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. When a person has a leaky gut, microorganisms, toxins, and medications can penetrate and cause a breach in the barrier.

The mucus layer is the first line of defense against infiltration of microorganisms, digestive enzymes and acids, digested food particles, microbial by-products, and food-associated toxins.(1) Some microbes use mucus as a prominent energy source; changes in mucus properties could alter, and even exacerbate, dysbiosis-related gut symptoms in neurological disorders.

What are the symptoms of leaky gut?

Chronic diarrhea, constipation, or bloating.
Nutritional deficiencies.
Fatigue.
Headaches.
Confusion.
Difficulty concentrating.
Skin problems, such as acne, rashes, or eczema.
Joint pain.

CLINICAL APPLICATIONS

Supports GI Barrier Health
Boosts Liver Function and Detoxification Pathways
Promotes Inflammatory Balance
Promotes Mucin Production in the GI tract

Overview

Under healthy conditions, the GI tract contains a semi- permeable epithelial mucosal barrier which protects against the unwanted passage of food antigens, toxins, and microorganisms from crossing directly into the bloodstream.

Several factors can affect the integrity of the epithelial barrier, including medications (particularly NSAIDs), stress, alcohol intake, injury, trauma, microbial imbalance, and poor nutrition. Reducing the impact of these factors and preserving a healthy GI tract is critical for maintaining long-term health.

In order to protect the mucosal barrier, a thick, complex layer of mucus is produced. From the stomach and throughout the intestines, the mucosa consists of a single layer of epithelial cells covered by a layer of secreted mucus. Like saliva, mucus is a complex fluid that is rich in mucin glycoproteins .

Mucin shields epithelial tissue from mechanical and chemical stress. Mucin also provides a broad range of immune support which helps maintain microbial balance.

Mucosagen includes L-glutamine, gamma oryzanol, N-acetyl glucosamine and lactoferrin to help support the health of the intestinal mucosal barrier and maintain healthy mucin production. Mucosagen also includes the additional benefit of N-acetyl cysteine and milk thistle to promote detoxification of harmful chemicals.

L-Glutamine†

L-glutamine is an amino acid that serves as a primary source of fuel for the small intestines. Epithelial cells in the small intestines (enterocytes) use L-glutamine as their metabolic fuel, which helps maintain mucosal growth, structure, and function.1

During times of stress, L-glutamine has been shown to be a conditionally essential amino acid, helping regenerate and maintain a healthy mucosal barrier.2 An increase in intestinal permeability can result in increased exposure to food, toxins, and microorganisms.

Inflammatory signals that are released during this exposure can trigger the stress hormone cortisol to increase the breakdown and utilization of L-glutamine in the small intestines.3 L-glutamine provides the primary fuel source for the gut mucosal lining to maintain the health of gut tissue.3

Gamma Oryzanol†

Gamma oryzanol is a natural component of rice bran oil. It is a mixture of ferulic acid esters of sterol and triterpene alcohols. Rice bran oil includes about 1-2% gamma oryzanol, which it functions as a highly effective antioxidant in the GI tract.

Gamma oryzanol has been shown to protect gastric mucosa from free radical stress and maintain normal inflammatory balance by inhibiting NFkB in macrophages.4,5

N-Acetyl Glucosamine†

N-acetyl glucosamine is the acetylated form of glucosamine. N-acetyl glucosamine is a mucin precursor and has been shown to increase the production of mucus within the GI tract.6

Colonic mucus production has been shown to be deficient in individuals with GI challenges.

Research has indicated that the step involving N-acetylation of glucosamine is deficient in patients with intestinal challenges.7-8 This can result in a decrease of glycoproteins that protect the intestinal mucosa.8

Lactoferrin†

Lactoferrin is a glycoprotein that is naturally found in colostrum, a milky fluid produced by the mammary glands. Lactoferrin plays a major role in supporting immune health, including both innate and adaptive immune functions.

Lactoferrin helps maintain normal microbial and inflammatory balance in the GI tract.9In animal studies, orally administered lactoferrin supported the health of the GI tract in mice, and provided protection against NSAID activity.10 Research has also indicated that lactoferrin can help maintain normal inflammatory balance in the gut by inhibiting TNFα and promoting cytokine IL-8.10

Silymarin (Milk Thistle Seed Extract) †

Milk thistle (Silybum marianum) is an annual plant indigenous to Europe and the United States and has been used for centuries as an herbal medicine to boost liver function.

The extract of milk thistle has silymarin, the biologically active component found in the seeds and leaves of this plant.

Silymarin provides liver- protective effects via several mechanisms of action, including inhibiting lipid peroxidation;11 supporting liver detoxification through enhancement of the liver’s glucuronidation pathways;12 and protection against glutathione depletion.13

Silymarin has been shown to increase hepatocyte protein synthesis resulting in hepatic tissue function.14

N-Acetyl Cysteine†

N-acetyl cysteine (NAC) is a sulfyhydryl containing amino acid that is commonly used to support liver and gut health. NAC is an effective precursor to the major antioxidant in the body, glutathione.

Oral supplementation with NAC has been shown to increase intracellular glutathione levels.15 NAC also stimulates a specific detoxification pathway in the liver called glutathione conjugation.16

Micronutrient Blend†

Mucosagen includes the synergistic nutrient combination of zinc, vitamin A, and biotin, which are crucial for supporting GI health.

Zinc is an essential mineral that is widely recognized for its role in gut and immune health. Zinc has been shown to strengthen GI barrier function by supporting the structure of tight junctions.16
Vitamin A is crucial for supporting GI integrity, maintaining normal inflammatory balance by reducing NFkB, and supporting mucus production.17
Biotin is an essential nutrient that is produced by several species of intestinal bacteria. Biotin deficiency is often present in individuals with GI challenges.18

Directions

2 capsules three times per day or as recommended by your health care professional.

Does Not Contain

Gluten, corn, yeast, artificial colors and flavors.

Cautions If you are pregnant or nursing, consult your physician before taking this product.

Quantity	180 CT, 90 CT

Mucosagen

Leaky Gut and The Mucous Barrier