Membrin -Memory Support

Membrin is designed to support and protect cognitive function and health. The formula includes 120 mg of standardized ginkgo biloba extract, 30 mg of vinpocetine and 100 mcg of huperzine A from Chinese club moss (Huperzia serrate), which work together to provide synergistic benefits for cognition and optimal protection for neurons. The brain, like the rest of the body, changes with age. Many people notice they become more forgetful as they age. It may take longer to think of a word or to recall a person’s name. If concerns with mental function go beyond what’s expected, the symptoms may be due to mild cognitive impairment (MCI).

Symptoms of Mild Cognitive Impairment

• You forget things more often.
• You miss appointments or social events.
• You lose your train of thought. Or you can’t follow the plot of a book or movie.
• You have trouble following a conversation.
• You find it hard to make decisions, finish a task or follow instructions.
• You start to have trouble finding your way around places you know well.
• You begin to have poor judgment.
• Your family and friends notice any of these changes.

If you have Cognitive Impairment, you also may experience:

• Depression
• Anxiety
• A short temper and aggression
• A lack of interest

Membrin contains Vinpocetine: Vinpocetine not only helps increase cerebral blood flow, it also works as a powerful antioxidant and anti-inflammatory in your brain all of which may improve the symptoms of mild cognitive impairment.

• Cerebral Circulation. Vinpocetine helps boost blood flow to and within the brain. Improving the flow of oxygen and glucose that feed ATP to power brain cells. Improving alertness, cognition, concentration, memory and mood.
• Neuroprotectant. Vinpocetine blocks the accumulation of sodium in neurons, reduces the toxic effects of oxidative stress, inhibits the enzyme PDE1 and boosting blood flow, scavenges free radicals, and protects neurons from glutamate and NMDA toxicity.
• Neuroplasticity. Vinpocetine inhibits the enzyme PDE1 which can increase cAMP and cGMP. These cyclic nucleotides in turn activate a series of kinases that phosphorylate the transcription factors cAMP response element binding protein (CREB) and serum response factor (SRF), leading to the expression of plasticity-related genes.[iii] Boosting neuroplasticity enhances cognition and memory.

Membrin CLINICAL APPLICATIONS

• Provides Protection for Neurons from Free Radical Damage
• Cognitive Impairment 
• Enhances Cerebral Blood Flow and Cognitive Health
• Provides Targeted Antioxidant Support for the Brain

Overview

Maintaining cognitive function is an increasingly important challenge with the aging United States population. Aging is often associated with functional changes in the brain that can affect event recall ability, thought organization, and ability for self-expression. While some memory loss is common in the aging population, factors such as free-radical damage, nutrient deficiencies, lifestyle choices, and emotional stress are known to affect cognition as we grow older. The brain is part of the nervous system, which is made up of neurons responsible for processing and transmitting information using neurotransmitters and electrical ion channels.

Neurotransmitter receptors are the gateways for communication between nerve cells. Maintaining the function of these various aspects of neuron communication is integral to maintaining good cognitive function. Since neurons do not undergo cell division, protecting them from damage is essential. Furthermore, maintaining optimal blood flow to neurons is also important in maintaining their health.

Membrin provides vinpocetine and ginkgo biloba to support cerebral blood circulation, decrease excitotoxicity and scavenge damaging free radicals. In addition, vinpocetine has specifically been shown to inhibit phosphodiesterase, which plays a role in increasing cerebrovascular blood flow and improving memory.

Together with huperzine A, a potent acetylcholine sparing nutrient, Membrin provides optimal dosages of three of the most well-studied ingredients for targeted,multidimensional cognitive support.

Ginkgo Biloba†

Ginkgo biloba extract is the most well-studied botanical for cognitive support. In addition to protecting overall neuronal function, ginkgo increases cerebral blood flow, and protects neurons from a variety of hypoxic conditions and oxidantinduced damage. In addition, ginkgo scavenges nitric oxidespecies (NOS) and reactive oxygen species (ROS), supports mitochondrial function, and inhibits NMDA receptor activation (a prominent pathway of brain decline), by reducing the overstimulation of neurons that cause brain fatigue.

Ginkgo has also been found to antagonize the platelet activating factor (PAF), a vasoconstrictor, and stimulate the release of NOS, increasing cerebral blood flow. Ginkgo has been shown to support memory in animal and human models. In a 14- day, double-blind study on the cognitive effects of a nutrient compound containing ginkgo biloba among 24 normal adults, a reliable 50 ms response time decrease was observed between the placebo and ginkgo biloba testing, suggesting that ginkgo supports short-term working memory processing in normal adults.

Vinpocetine†

Synthesized from tabersonine, a natural extract from the seeds of the West African plant Voacanga africana, vinpocetine has recently been the subject of research related to cognitive health because of its neuroprotective mechanisms, including its antioxidant, and vasodilating activities. Vinpocetine has the ability to cross the blood brain barrier, and has vasorelaxant effects on cerebral smooth muscle tissue. In one 12-week study, a significant improvement was found in cognitive functions after subjects were given oral vinpocetine therapy using psychometric tests.

Specifically, vinpocetine has also been shown to improve oxygen-release from hemoglobin, helping to maintain red blood cell flexibility, allowing the cells to pass more easily through tiny capillaries. Furthermore, studies have shown vinpocetine moderates the excitotoxicity of neurotransmitters, enhancing nerve cell health by inhibiting sodium channels and reducing intracellular calcium levels.

Huperzine A†

A purified component derived from Chinese club moss, huperzine A has been found to support healthy cognition in a range of animal models, and phase IV clinical trials demonstrated its promotion of improved recall and cognition in elderly subjects. As a potent and selective acetylcholinesterase inhibitor, huperzine A helps to improve memory and support optimal cognitive health. A multicenter, prospective, doubleblind, placebo controlled and randomized study gave 50 patients 0.2 mg of huperzine A and compared them to a group given a placebo for eight weeks.

They found that 58% (29/50) of patients treated with huperzine A showed improvements in their memory, cognitive and behavioral functions. A second double-blind and matched pair study looked at 34 pairs of middle school students complaining of memory inadequacy and divided them into two groups by psychological health inventory (PHI), similar memory quotient and same sex and class. After four weeks, the huperzine A group, (50 mcg twice a day) showed twice the improvement of the placebo group.

Dosage

1 capsule per day or as recommended by your health care professional.

Does Not Contain

Gluten, yeast, artificial colors and flavors.

Cautions

Do not consume Membrin if you are pregnant or nursing.Consult your physician for further information