CDG EstroDIM

Are you searching for a natural supplement that helps with estrogen metabolism? CDG EstroDIM is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism in both men and woman. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites to support estrogen balance and breast and prostate health.

Metabolites†

Many of the health benefits derived from eating cruciferous vegetables (cabbage, brussels sprouts, broccoli, etc.), especially those that may be beneficial for breast and prostate health, are thought to be derived from the group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed or chewed the enzyme myrosinase (released from the cells) hydrolyses these glucosinolates into other compounds. For instance, glucosinolates from broccoli and Brussels sprouts readily convert into I3C when consumed. I3C can then be further converted via stomach acid into other health-promoting compounds, including DIM. These compounds are generally thought to be responsible for the various cellular activities that lead to hormone health.

Overview

Estrogen collectively refers to the female hormones estradiol, estrone, and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver to cells is to grow, divide, and multiply.

For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism, and detoxification is essential for proper hormonal balance. How estrogen is metabolized can result in different metabolites, each with individual biological activity. By keeping hormones in balance and ensuring the body can process hormones properly, cruciferous vegetable metabolites (such as I3C and DIM) work together to reduce hormone overload and maintain cellular health.

Current data on I3C and DIM suggests that these phytonutrients have strong potential for supporting breast, cervical, uterine, and prostate health. Together, I3C and DIM promote the creation of the favorable and protective 2-hydroxy-estrone (2-OHE) metabolite versus the production of 4-hydroxy-estrone (4-OHE) and 16-alpha-hydroxy estrone (16-alphaOHE), metabolites which can overstimulate cells and create free radicals that cause DNA damage. The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of the 2:16-alphaOHE ratio has been used to evaluate breast health. With this in mind, CDG EstroDIM includes targeted doses of both I3C and DIM in a two-capsule per day dosing to make daily balancing of hormones easy and convenient.

Why We Recommend CDG EstroDim

• Supports Estrogen Balance in both Men and woman
• Supports Proper Estrogen Metabolism for Women and Men
• Improves Estrogen Detoxification Pathways and Hormone Excretion
• Provides Cellular Antioxidant Support for DNA Stability

Estrogen Dominance 

Estrogen dominance refers to a hormonal imbalance where there is an excess of estrogen relative to other hormones, such as progesterone, in the body. While estrogen is an essential hormone for various physiological functions, including reproductive health, an imbalance in estrogen levels can lead to various health issues and complications. Some potential problems associated with estrogen dominance include:

1. Menstrual Irregularities: Estrogen dominance can disrupt the normal menstrual cycle, leading to irregular periods, heavy or prolonged bleeding, or even missed periods. This hormonal imbalance can contribute to symptoms such as menstrual cramps and bloating.

2. Mood Swings and Emotional Disturbances: Estrogen plays a role in regulating neurotransmitters in the brain, and an excess of estrogen can disrupt this balance, leading to mood swings, irritability, anxiety, and even depression.

3. Fibroids and Endometriosis: Elevated levels of estrogen have been associated with the growth of uterine fibroids and the development of endometriosis, both of which can cause pelvic pain, heavy bleeding, and fertility issues.

4. Breast Tenderness and Swelling: Estrogen dominance can contribute to breast tissue sensitivity and swelling, leading to discomfort or pain.

5. Weight Gain and Difficulty Losing Weight: An imbalance between estrogen and progesterone can hinder the body’s ability to regulate weight, making it more challenging to lose excess weight or maintain a healthy weight.

6.Postate Hypertrophy- Prostate enlargement, also known as benign prostatic hyperplasia (BPH), is a common condition that affects many aging men. Estrogen, along with other hormones, plays a role in the development and growth of the prostate gland.

I3C†

I3C (indole-3-carbinol) is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale, and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.

DIM†

Diindolylmethane (DIM) is a phytonutrient and plant indole also found in cruciferous vegetables with the potential for enhancing the proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes, supporting the formation of healthy estrogen metabolites and enhancing the potential for greater antioxidant activity.

What Calcium D-Glucarate Does

Calcium D-Glucarate helps support a detox pathway called glucuronidation, one of the body’s Phase II liver detoxification pathways. This pathway helps the body bind and eliminate:

• Estrogens
• Environmental toxins
• Used-up hormones
• Certain chemicals
• Some bile-related waste products

One of its main actions is inhibiting beta-glucuronidase, an enzyme produced by certain gut bacteria. When beta-glucuronidase is elevated, it can “unhook” toxins and hormones that were supposed to be eliminated, allowing them to be reabsorbed back into circulation. Research shows calcium D-glucarate can inhibit beta-glucuronidase activity, though much of the strongest evidence is preclinical or animal-based.

Elevated Beta-Glucuronidase on Stool Testing

This is one of the most practical uses. If a stool test shows high beta-glucuronidase, Calcium D-Glucarate may be used to help reduce the reactivation and reabsorption of toxins and hormones in the gut.

This can be especially relevant in people with:

• Gut dysbiosis
• Constipation
• Sluggish detoxification
• Hormone-related symptoms
• History of toxic exposures
• Mold illness patterns
• Estrogen clearance problems

Directions

2 capsules per day or as recommended by your health care professional.

Does Not Contain

Wheat, gluten, corn, yeast, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

Cautions

Do not consume this product if you are pregnant or nursing.