Histamine Intolerance DAO Enzymne Support Pack (updated)
Comprehensive Histamine Support. Save when you purchase Dr Hagmeyers Histamine Support Pack.
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Supplements to Help with Histamine Intolerance- Histamine Support Pack
Histamine intolerance occurs when there is a buildup of histamine in the body. Drugs, medical conditions, the environment, nutritional deficiencies, and diet can lead to histamine intolerance.
Factors that lead to histamine intolerance cause the following:
- An increase in how much histamine a person’s digestion releases.
- A decrease in the effectiveness or abundance of diamine oxidase, or DAO, the primary enzyme that breaks down ingested histamine.
- A decrease in the effectiveness or abundance of histamine-N-methyltransferase, or HNMT, an enzyme that helps break down histamine within cells.
Common factors that interfere with DAO and HMNT levels include many prescription drugs, for example:
- airway medications, such as theophylline
- heart medications
- antibiotics
- antidepressants
- antipsychotics
- diuretics
- muscle relaxants
- pain medications
- gastrointestinal medicines
- nausea and gastroesophageal reflux disease, GERD
- malaria drugs
- tuberculosis medications
The list also includes over-the-counter (OTC) and prescription anti-inflammatories (NSAIDs) and painkillers, such as:
- acetylsalicylic acid (aspirin)
- indomethacin (Indocin)
- diclofenac (Voltaren)
- naproxen
Other influencing factors include:
- alcohol
- intestinal conditions or injuries that compromise the gut lining and affect digestion
- liver conditions
- vitamin B-6, vitamin C, copper, or zinc deficiencies
- extreme or chronic stress
- low oxygen states
- injury or trauma
- temperature extremes
Histamine Intolerance Support #1 PureGG 25B
Clinical Applications
- Highly researched Lactobacillus rhamnosus GG to support immune, G.I., and overall health across all ages‡
- Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells
- L. rhamnosus protects the mucus barrier of the intestine by stimulating the production of mucins from globlet cells, and also reduces intestinal inflammation by inhibiting the production of pro-inflammatory cytokines and ROS.
- Provides 25 billion CFU per capsule, one of the most characterized and clinically studied probiotic strains on the market
Probiotics, which are beneficial bacteria that support the gut microbiome, have been shown to offer potential benefits for individuals with histamine intolerance or Mast Cell Activation Syndrome (MCAS).
Certain types of bacteria can produce histamine, whereas some may have the ability to degrade histamine, and some have no direct effect on histamine.
Here’s how probiotics like Pure GG may help alleviate symptoms associated with these conditions:
1. Gut Microbiome Balance: Imbalances in the gut microbiome can contribute to increased histamine levels and dysregulated immune responses. Probiotics help restore microbial balance by promoting the growth of beneficial bacteria and inhibiting the growth of harmful pathogens. A healthy gut microbiome is crucial for proper histamine metabolism and immune system function.
2. Histamine Degradation: Certain strains of probiotics, have demonstrated the ability to produce enzymes like diamine oxidase (DAO) that help break down histamine in the digestive tract. By enhancing histamine degradation, probiotics can potentially lower systemic histamine levels and alleviate symptoms.
In other studies, L. rhamnosus GG® appears to have a positive effect on histamine levels by downregulating the IgE and histamine receptors, up-regulating anti-inflammatory agents in the gut therefore helping reduce intestinal permeability or pathogenic bacteria from adhering to the gut wall. (*),(*),(*)
3. Regulation of Immune Responses: Probiotics can modulate immune responses, preventing excessive activation of mast cells and subsequent histamine release. They support immune system balance by modulating the production and activity of pro-inflammatory cytokines, which can help control inflammatory reactions associated with histamine intolerance and MCAS.
4. Gut Barrier Function: Probiotics play a significant role in maintaining the integrity of the gut barrier, which prevents the leakage of undigested food particles, toxins, and histamine into the bloodstream. By strengthening the gut barrier, probiotics help reduce the entry of histamine-triggering substances, potentially easing symptoms of histamine intolerance and MCAS.
5. Anti-inflammatory Effects: Probiotics produce bioactive compounds, such as short-chain fatty acids (SCFAs), that possess anti-inflammatory properties. By reducing inflammation in the gut and systemically, probiotics can help address the underlying inflammation associated with histamine intolerance and MCAS.
Histamine Intolerance Support #2 Pomegranate Plus
Clinical Applications
- Antihistamine Effects
- Mast Cell Stabilization
- Anti-Inflammatory IL-6, IL IL-8, NFkB, MAPK cascade
- Immune Modulator
Beyond its delicious taste and vibrant color, pomegranate extract holds the potential for antihistamine properties and mast cell stabilization effects. These benefits of pomegranate extract are thanks in part to its rich content of Flavonoids,polyphenols, anthocyanins, punicalagins. (*)
Pomegranate Extract and Inflammation.
Histamines are natural compounds released by the body in response to allergens, causing typical allergy symptoms like sneezing, itching, congestion and hives.
Mast cells and basophils are white blood cells that can be found throughout the body and contain plentiful secretary granules which when ruptured release histamine.
Mast Cells and Basophils are involved in several inflammatory and immune events and are known to produce an array of mediators including a broad spectrum of inflammatory cytokines.
An overactive mast cell response can lead to excessive histamine release and allergy symptoms. Hence, substances that offer antihistamine and mast cell stabilization effects can be beneficial in managing allergies.
Pomegranate fruit is rich in anthocyanins and hydrolysable tannins; a group of polyphenolic compounds shown to be potent antioxidants with anti-inflammatory activity.
Compounds found in pomergranite extract have been shown to significant decrease IL-6, IL-8 and NF-kB which in turn can suppress mast cell and basophil activation. (*)
The Power of Pomegranate Extract
Pomegranate extract, derived from the fruit’s seeds, contains potent antioxidant compounds like punicalagins, ellagic acid, and anthocyanins. These components have been shown to possess remarkable anti-inflammatory properties and the ability to modulate immune responses. Studies suggest that pomegranate extract may act as an effective natural remedy for alleviating allergy symptoms by working as an antihistamine and stabilizing mast cells.
Antihistamine Effects of Pomegranate Extract
Research has indicated that pomegranate extract exhibits antihistamine effects by inhibiting the release of histamines in the body. It can potentially block histamine receptors, reducing the allergic response. This action may provide relief from common allergy symptoms such as itching, congestion, and watery eyes, among others.
Pomegranate extract’s antihistamine effects make it a promising natural alternative for managing allergies without the drowsiness often associated with over-the-counter antihistamines.
Mast Cell Stabilization Effects of Pomegranate Extract
In addition to its antihistamine properties, pomegranate extract may also help stabilize mast cells. By reducing mast cell degranulation, pomegranate extract can limit the release of histamines and other inflammatory substances.(*) This mechanism provides further relief from allergy symptoms and may aid in preventing severe allergic reactions. By regulating mast cell activity, pomegranate extract promotes a more balanced immune response, reducing excessive inflammation associated with allergies.
Pomegranate extract’s beneficial properties extend beyond its delightful taste. Its potential as a natural antihistamine and mast cell stabilizer makes it a promising solution for managing allergies and related conditions. Exploring the science-backed benefits of pomegranate extract opens up new possibilities for those seeking effective and natural approaches to allergy and histamine intolerance relief.
Histamine Intolerance Support #3 Hist Reset
Clinical Applications
- Multi-faceted support for nasal and respiratory health‡
- Promotes healthy mast cell stabilization‡
- Supports healthy histamine metabolism‡
- 100 mg luteolin per serving
- Includes flavonoids quercetin, luteolin, and rutin for antioxidant and immune support‡
Histamine is a substance found in many foods such as meat, spinach, avocadoes, nuts, tomatoes, and chocolate, or released as part of the local immune response by immune cells, primarily mast cells, upon exposure to an immune trigger. Some individuals have difficulty breaking down histamine.1
This formula is designed to modulate mast cell and immune mediator activation, support healthy histamine metabolism, and promote respiratory and tissue health.
Quercetin, luteolin, and rutin are flavonoids known to exhibit antioxidant and immune modulating activity. In vitro studies involving mast cells suggest that these compounds help to stabilize mast cells and modulate the release of immune mediators, including histamine, leukotrienes and prostaglandins.(*),(*),(*)
The mechanism of action is believed to be in part due to modulating extracellular signal-regulated kinases, including PKC.
Animal studies suggest that these flavonoids can moderate IgE antibody’s mediated response in skin.(*)
Histamine Intolerance Support #4 Perilla Extract
Clinical Applications
- Supports healthy modulation of Th2 cytokines,
- Supports Modulation of eosinophil and mast cell activity‡
- Maintains healthy modulation of mucosal immune responses to environmental factors‡
- Offers perilla seed extract for more concentrated polyphenols, rosmarinic acid, luteolin, and other beneficial compounds compared to leaf.
Perilla extract has been a subject of interest when it comes to allerigies and other IgE mediated immune system problems. Perilla extract is also an area of research when ti come to Histamine intolerance.
Due to its potential to modulate IgE levels in the body. IgE (Immunoglobulin E) is an antibody involved in allergic responses and is responsible for triggering the release of histamines and other inflammatory substances.
Here’s how perilla extract may affect IgE levels:
1. Anti-Allergic Properties: Perilla extract contains bioactive compounds such as rosmarinic acid and luteolin, which possess anti-inflammatory and antioxidant properties. These components may help attenuate the allergic response by inhibiting the production and activation of IgE antibodies.
2. IgE Synthesis Inhibition: Studies have suggested that perilla extract may have the ability to suppress the synthesis of IgE antibodies, thus reducing the overall levels of IgE in the body. By inhibiting IgE production, perilla extract may dampen the allergic response and alleviate allergic symptoms.
3. Mast Cell Stabilization: Perilla extract has been found to exhibit mast cell stabilizing effects. Mast cells play a significant role in the release of histamines and other allergic mediators in response to IgE activation. By stabilizing mast cells, perilla extract may decrease excessive histamine release and subsequent allergic reactions.
4. Allergy Prevention: Some studies have shown that perilla extract has a preventive effect on allergic sensitization, possibly by impacting IgE levels. By modulating IgE production and allergic immune responses, perilla extract offers a potential means of reducing the risk of developing allergies.
Histamine Intolerance Support #5 Histamine DAO enzymes
- Helps break down histamine: DAO enzymes metabolize histamine in the gut, preventing excess histamine from entering the bloodstream. Supports relief from histamine
- Supports relief from histamine intolerance symptoms: Supplementing DAO may reduce symptoms like headaches, hives, nasal congestion, flushing, or digestive discomfort caused by high histamine levels.
- Improves digestive health: By assisting in histamine breakdown, DAO can help reduce gut inflammation and support a healthier intestinal environment.
- May improve food tolerance: People sensitive to histamine-rich foods (like aged cheeses, wine, or fermented foods) may tolerate them better with adequate DAO levels.
🧬 What is the DAO Enzyme?
Diamine oxidase (DAO) is an enzyme primarily responsible for breaking down histamine, a compound involved in immune responses, digestion, and the nervous system.
⚙️ What Does DAO enzymes Do?
DAO mainly:
Degrades histamine in the digestive tract and bloodstream.
Helps regulate histamine levels from food and internal processes.
Prevents histamine buildup, which could trigger allergic-like symptoms.
📍 Where Is DAO Found?
DAO is produced in:
Intestinal lining (small intestine) – main site.
Kidneys
Thymus
Placenta (during pregnancy) – which is why pregnant women often have higher DAO levels.
❗ Why Is DAO enzymes Important?
If the body doesn’t produce enough DAO, or if its function is inhibited, histamine levels can rise — this is known as histamine intolerance.
Common symptoms of low DAO or histamine intolerance include:
Headaches or migraines
Flushing or skin rashes (like hives)
Nasal congestion
Digestive issues (bloating, diarrhea)
Rapid heartbeat or dizziness
🥦 How to Support DAO enzymes?
Foods rich in DAO or supportive nutrients include:
Copper sources (DAO is copper-dependent): nuts, seeds, whole grains
Vitamin B6 and C: bananas, spinach, peppers, citrus
Fresh, unprocessed foods instead of aged/fermented foods (which are high in histamine)
Some people take DAO supplements before meals to help with histamine breakdown — especially if enzyme production is low.